Immunology question
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Which complement component is the most potent anaphylatoxin?
A. C1q
B. C3a
C. C4b
D. C5a
E. C9
@surgery@isurg.org
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Anaphylatoxins are complement fragments that trigger mast cell degranulation → histamine release → vasodilation, increased vascular permeability, and smooth muscle contraction.
Main anaphylatoxins: C3a, C4a, C5a.
Of these, C5a is the most potent → also a powerful chemotactic factor for neutrophils.
C1q, C4b, C9 are not anaphylatoxins.