Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine in Adults ≥50 YearsA Randomized Clinical Trial
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Question Is a multicomponent vaccine against seasonal influenza and SARS-CoV-2 (mRNA-1083) immunogenic and well-tolerated in adults 50 years and older?
Findings In this phase 3 study, mRNA-1083 elicited noninferior immune responses against standard care immunization: licensed standard-dose or high-dose seasonal influenza vaccine (A/H1N1, A/H3N2, B/Victoria, B/Yamagata) coadministered with licensed SARS-CoV-2 (Omicron XBB.1.5) vaccine. The multicomponent vaccine mRNA-1083 had an acceptable tolerability and safety profile.
Meaning mRNA-1083 was demonstrated to be at least as immunogenic as recommended standard care vaccines against both seasonal influenza and COVID-19 and well-tolerated in adults 50 years and older.
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Question Is a multicomponent vaccine against seasonal influenza and SARS-CoV-2 (mRNA-1083) immunogenic and well-tolerated in adults 50 years and older?
Findings In this phase 3 study, mRNA-1083 elicited noninferior immune responses against standard care immunization: licensed standard-dose or high-dose seasonal influenza vaccine (A/H1N1, A/H3N2, B/Victoria, B/Yamagata) coadministered with licensed SARS-CoV-2 (Omicron XBB.1.5) vaccine. The multicomponent vaccine mRNA-1083 had an acceptable tolerability and safety profile.
Meaning mRNA-1083 was demonstrated to be at least as immunogenic as recommended standard care vaccines against both seasonal influenza and COVID-19 and well-tolerated in adults 50 years and older.
"Conclusions and Relevance In this study, mRNA-1083 met noninferiority criteria and induced higher immune responses than recommended standard care influenza (standard and high dose) and COVID-19 vaccines against all 4 influenza strains (among those ages 50-64 y), the 3 clinically relevant influenza strains (among those aged ≥65 y), and SARS-CoV-2 (all ages), with an acceptable tolerability and safety profile."
Yes, it's totally doing what it's made to do.
It seems like you're here to dispute that by doing this dumbshittery of "just asking questions", as if the outcome is not exactly what it says it is.
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"Conclusions and Relevance In this study, mRNA-1083 met noninferiority criteria and induced higher immune responses than recommended standard care influenza (standard and high dose) and COVID-19 vaccines against all 4 influenza strains (among those ages 50-64 y), the 3 clinically relevant influenza strains (among those aged ≥65 y), and SARS-CoV-2 (all ages), with an acceptable tolerability and safety profile."
Yes, it's totally doing what it's made to do.
It seems like you're here to dispute that by doing this dumbshittery of "just asking questions", as if the outcome is not exactly what it says it is.
Reading the post, linked article, and your comment I'm wondering: aren't you guys on the same side (stating that vaccines work)?
I could be wrong but I don't see @otters_raft@lemmy.ca disputing the efficacy of vaccines and is in fact doing the opposite in providing evidence that vaccines do work.
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"Conclusions and Relevance In this study, mRNA-1083 met noninferiority criteria and induced higher immune responses than recommended standard care influenza (standard and high dose) and COVID-19 vaccines against all 4 influenza strains (among those ages 50-64 y), the 3 clinically relevant influenza strains (among those aged ≥65 y), and SARS-CoV-2 (all ages), with an acceptable tolerability and safety profile."
Yes, it's totally doing what it's made to do.
It seems like you're here to dispute that by doing this dumbshittery of "just asking questions", as if the outcome is not exactly what it says it is.
This community is intended for healthcare professionals
As per the article
Importance Uptake of recommended seasonal influenza and COVID-19 vaccines remains suboptimal.
Objective To assess the immunogenicity and safety of an investigational mRNA-1083 vaccine against seasonal influenza and SARS-CoV-2 in adults 50 years and older.
Being able to cite data about safety and effectiveness is helpful when making recommendations to patients, and necessary when healthcare professionals are discussing policy.
I included the results in the post body to make sure it wasn't clickbait or misleading, but I'm always looking to improving it in the future if you have feedback
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