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  3. Maybe there was a cure for human cancer, but it didn't work at all in mice.

Maybe there was a cure for human cancer, but it didn't work at all in mice.

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  • tinfox@lemmy.worldT tinfox@lemmy.world
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    the_q@lemmy.zip
    wrote last edited by
    #5

    Cancer can't be cured because it isn't 1 thing. And animal testing regardless of the benefit humans may receive is morally wrong.

    C 1 Reply Last reply
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    • tinfox@lemmy.worldT tinfox@lemmy.world
      This post did not contain any content.
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      rowinxavier@lemmy.world
      wrote last edited by
      #6

      The crazy thing is we actually do have things that work in humans but not in mice. Mice are omnivores and are very different in terms of optimal energy state. They tend to run in glucose more easily than on fat and their whole biology is built to be small and fast, with short life spans.

      Checking how DNA repair works in an animal which lives for maybe 2 years is great for understanding DNA repair in short lived organisms, but we have tk repair damage for 50 times as long. It is just so much more complex and requires such different tools when you switch from maybe 2 years to maybe 80 years, it really isn't sane to assume it will all carry over.

      Now for an accute toxin, say tobacco, sure, some things work just fine. There is not a huge difference between humans and mice when subjected to cyanide or arsenic. Being crushed by a falling piano is going to kill both of us. But a chronic poison? That will take decades to kill? That is very different. We can shed cells in a different way to how they can. We have more mass to store things. We have more energy storage. We have bigger kidneys with more opportunities for filtering. We are different.

      When we enter ketosis we have some fairly significant cancer responses. When we maintain fasting for 5+ days we have a fairly large bump in autophagy, a state where the body kills off and recycles damaged cells. This state can cause some types of cancer to be more obvious to our immune systems and allow the tumor to be attacked. In some cases otherwise inoperable tumors can be removed after shrinking them through fasting. This does not replicate in mice. So yes, some treatments (not cures because that doesn't really apply) do work in humans and not in mice.

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      • T triumph@fedia.io

        Cancer isn’t one thing.

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        baggachipz@sh.itjust.works
        wrote last edited by
        #7

        The whole concept of “curing cancer” is such a trope. Cancer is a condition, and it annoys the fuck out of me that people treat it as one disease like measles or the flu.

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        • tinfox@lemmy.worldT tinfox@lemmy.world
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          credibly_human@lemmy.world
          wrote last edited by
          #8

          I mean, there are like dozens of different types of cancers, so we probably have missed some of them.

          L 1 Reply Last reply
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          • T the_q@lemmy.zip

            Cancer can't be cured because it isn't 1 thing. And animal testing regardless of the benefit humans may receive is morally wrong.

            C This user is from outside of this forum
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            credibly_human@lemmy.world
            wrote last edited by
            #9

            And animal testing regardless of the benefit humans may receive is morally wrong.

            You can say whatever you want, but just because you feel it really hard doesnt mean it will be convincing to other people.

            In this particular case, I think animal testing is moral as fuck, because why in the fuck would I possibly value animal lives even close to that of a human or myself.

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            • O ozymandias@lemmy.dbzer0.com

              they use a lot of other things… including living human cancer cells in a petri dish

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              bastingchemina@slrpnk.net
              wrote last edited by
              #10

              I believe the vast majority of cultivated human cells are cancerous cells anyway.

              Link Preview Image
              Henrietta Lacks - Wikipedia

              favicon

              (en.wikipedia.org)

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              • C credibly_human@lemmy.world

                And animal testing regardless of the benefit humans may receive is morally wrong.

                You can say whatever you want, but just because you feel it really hard doesnt mean it will be convincing to other people.

                In this particular case, I think animal testing is moral as fuck, because why in the fuck would I possibly value animal lives even close to that of a human or myself.

                T This user is from outside of this forum
                T This user is from outside of this forum
                the_q@lemmy.zip
                wrote last edited by
                #11

                Why do you matter more than any other animal?

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                • B bastingchemina@slrpnk.net

                  I believe the vast majority of cultivated human cells are cancerous cells anyway.

                  Link Preview Image
                  Henrietta Lacks - Wikipedia

                  favicon

                  (en.wikipedia.org)

                  O This user is from outside of this forum
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                  ozymandias@lemmy.dbzer0.com
                  wrote last edited by
                  #12

                  when researching cancer drugs, yeah

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                  • C credibly_human@lemmy.world

                    I mean, there are like dozens of different types of cancers, so we probably have missed some of them.

                    L This user is from outside of this forum
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                    lightfire228@pawb.social
                    wrote last edited by
                    #13

                    imo, there's no single "cure" for cancer, because it's not a single disease

                    J 1 Reply Last reply
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                    • L lightfire228@pawb.social

                      imo, there's no single "cure" for cancer, because it's not a single disease

                      J This user is from outside of this forum
                      J This user is from outside of this forum
                      jet@hackertalks.com
                      wrote last edited by
                      #14

                      There is debate on that. There is a mitochondrial model of cancer that unifies cancer into a single mechanic. https://doi.org/10.3389/fcell.2015.00043

                      This is different from the common somatic mutation theory which views cancer as a bad generic mutation of human DNA

                      1 Reply Last reply
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                      • R rowinxavier@lemmy.world

                        The crazy thing is we actually do have things that work in humans but not in mice. Mice are omnivores and are very different in terms of optimal energy state. They tend to run in glucose more easily than on fat and their whole biology is built to be small and fast, with short life spans.

                        Checking how DNA repair works in an animal which lives for maybe 2 years is great for understanding DNA repair in short lived organisms, but we have tk repair damage for 50 times as long. It is just so much more complex and requires such different tools when you switch from maybe 2 years to maybe 80 years, it really isn't sane to assume it will all carry over.

                        Now for an accute toxin, say tobacco, sure, some things work just fine. There is not a huge difference between humans and mice when subjected to cyanide or arsenic. Being crushed by a falling piano is going to kill both of us. But a chronic poison? That will take decades to kill? That is very different. We can shed cells in a different way to how they can. We have more mass to store things. We have more energy storage. We have bigger kidneys with more opportunities for filtering. We are different.

                        When we enter ketosis we have some fairly significant cancer responses. When we maintain fasting for 5+ days we have a fairly large bump in autophagy, a state where the body kills off and recycles damaged cells. This state can cause some types of cancer to be more obvious to our immune systems and allow the tumor to be attacked. In some cases otherwise inoperable tumors can be removed after shrinking them through fasting. This does not replicate in mice. So yes, some treatments (not cures because that doesn't really apply) do work in humans and not in mice.

                        J This user is from outside of this forum
                        J This user is from outside of this forum
                        jet@hackertalks.com
                        wrote last edited by
                        #15

                        When we maintain fasting for 5+ days we have a fairly large bump in autophagy, a state where the body kills off and recycles damaged cells. This state can cause some types of cancer to be more obvious to our immune systems and allow the tumor to be attacked. In some cases otherwise inoperable tumors can be removed after shrinking them through fasting.

                        Cancer cells can't metabolize fat, when your fasting and in ketosis your body is only supplying fat and the cancer has nothing to eat (mostly, there is some glucose produced as a baseline)

                        I.E. fasting slows down the cancer energy rate so that the immune system can start catching up.

                        This is why the press-pulse cancer protocol uses deep ketosis and fasting in addition to supreasing the bodies glucose production. I.e. never adding external sugar into the body at all during treatment.

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                        • T the_q@lemmy.zip

                          Why do you matter more than any other animal?

                          J This user is from outside of this forum
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                          jet@hackertalks.com
                          wrote last edited by jet@hackertalks.com
                          #16

                          Your philosophy is antithetical to existence.

                          Being alive kills other things, nature is competition. From bacteria and viruses in your body constantly being killed, to animals in the food supply (even veggies and croplands have pest control), just living in a safe community relies on the killing of other life: removing dangerous animals from the community, keeping pests out of food stores, keeping the water clean (kills water based life)

                          The phone you are using is at the end of a very complicated supply chain that mines resources from the earth, which requires killing animals... Moving resources across the earth, which requires killing animals (fish hit by boats, animals run over by cars, birds hit by trucks, pest control in all the production and storage facilities), etc.

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                          • B baggachipz@sh.itjust.works

                            The whole concept of “curing cancer” is such a trope. Cancer is a condition, and it annoys the fuck out of me that people treat it as one disease like measles or the flu.

                            J This user is from outside of this forum
                            J This user is from outside of this forum
                            jet@hackertalks.com
                            wrote last edited by
                            #17

                            There are some unifying theories of cancer that do kinda make it into one thing:
                            https://doi.org/10.3389/fcell.2015.00043

                            I.e. the Warburg effect, and damaged mitochondria being st the root of all cancers.

                            In your example the flu is not just one thing either, it's a group of viruses that broadly have the same symptoms

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                            • O ozymandias@lemmy.dbzer0.com

                              when researching cancer drugs, yeah

                              J This user is from outside of this forum
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                              jet@hackertalks.com
                              wrote last edited by jet@hackertalks.com
                              #18

                              Actually it's used in everything, it's available, it's well studied, it's cheap, and most importantly it grows fast in a lab, so it's easy to work with....

                              I wish I was joking, but lots of in vitro human research is done on the poor women's cancer cells when the research has nothing to do with cancer, it's quite the confounder

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